ACTIVE FREEZE DRYER The Active Freeze Dryer AFD offers profound advantages over traditional tray freeze dryersIt is designed to produce freeflowing sterile bulk pharmaceuticals in a onepot process with no operator intervention and no postprocessingThe result is always a fine loose powder directly available from the product collector.
Active Freeze Dryer Hosokawa MicronHosokawas Active Freeze Drying system eliminates this drawback and is a big step forward in the field of freeze drying thermosensitive bulk solids as well as in powder technology in generalDue to the agitated freeze drying process different product characteristics can be improved without the need of.
Active Freeze Drying AFD technology introduced by Hosokawa is able to eliminate all these disadvantages Tray based lyophilization – In a conventional tray freeze dryer system the plates are filled with the liquid productThe product is then cooled and frozenOnce frozen mostly in the vacuum chamber the vacuum is applied and the.
Active Freeze Drying another Hosokawa innovationFreezedrying or lyophilization is the sublimation of a solvent which has been crystallised at low temperaturesThe solvent is sublimated from the solid state direct into the vapour phase.
Active Freeze Drying A shorter and less laborintensive drying process and the possibility to produce a nonlumpy and therefore easy to process uniform powder under low temperatures and low pressureEven this very brief introduction clearly illustrates that the Hosokawa Stirred Freeze Dryer patent pending can be seen as a big step forward in.
As the solvent disappears the product temperature starts to rise until it equals the jacket temperatureThis marks the end of the drying processOnce the vacuum has been released the chamber is opened and the powdered product can be discharged.
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Developed Active Freeze Drying technology is seen as an important step in the world of freeze drying and powder technologyThe Active Freeze Dryer consists of a specially designed drying chamber and collecting filterIn the chamber the material to be dried is frozen very quickly with the aid of a freezing medium.
Early experiments at Hosokawa Micron BV in Doetinchem starting about 10 years ago with a conventional vacuum dryer operated at low temperatures and ultralow pressures showed that it was possible to operate a freeze dryer under active conditionsThe result was a lumpfree freeflowing product.
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Experiments with an agitated vacuum dryer operated at low temperature and low pressure showed that it is possible to produce a lumpfree freeflowing freeze dried productActive freeze dryers also have a better heat transfer rate due to the continuous mixing of the product thus shortening the drying process Finally the freezing step is simplified because it can be done in the same vessel instead of having a separate freezing unit which results in easy handling of the product compared to tray drying equipment.
Freeze drying lyophilisation has been used industrially for decadesHowever traditional traytype freeze dryers are labour intensiveHosokawas Active Freeze Drying system eliminates this drawback and is a big step forward in the field of freeze drying thermosensitive bulk solids as well as in powder technology in general.
Freeze drying lyophilisation has been used industrially for decadesHowever traditional traytype freeze dryers are labour intensiveHosokawas Active Freeze Drying system eliminates this drawback and is a big step forward in the field of freeze drying thermosensitive bulk solids as well as in powder technology in generalDue to the agitated freeze drying process different product characteristics can be improved without the need of postprocessing steps.
Has developed a quicker and less laborintensive freeze drying process that can produce freeflowing powders from a single process vesselKnown as Active Freeze Drying technology the new process uses continuous motion to improve mass transfer and hence cut processing time while also eliminating the need to transfer.
Hosokawa Micron’s Active Freeze Dryer eliminates this drawback and offers more efficiency minimal handling and optimal product qualityCeuticals like antibiotics proteins collagens API’s and electrolytes.
In an Active Freeze Dryer the product is first frozen dynamically by moving it in a specially designed chamberWhether the material to be dried starts off as a liquid granular solid or paste the forced motion inside the drying chamber ensures that it freezes in the form of freeflowing solid granules.
Mar 24 2017nbsp018332There is no requirement for additional containment equipment to protect operators or product for this packoff stageHosokawa Micron’s Active Freeze Drying system is capable of drying solutions dispersions pastes and wet solids with successful applications including antibiotics APIs proteins collagens and electrolytes.
Mar 27 2017nbsp018332Hosokawa Micron’s active freeze drying technology incorporates the use of a jacketed and stirred dryer and collection filter Figure 1Material is quickly frozen inside the vesselWhen the vacuum is broken on cycle completion he adds the finished dry powder is discharged directly into a container that was sterilised before.
Once the product is fully frozen a deep vacuum is applied and the sublimation startsHeat applied to the vessel jacket is effectively distributed throughout the product due to the dynamic environmentThe initially coarse frozen granules gradually shrink as the ice structure connecting the frozen material sublimes yielding a loose powder consisting of fine dry particles.
The Active Freeze Drying system offers unique possibilities for freeze drying various types of materials in one processing step always resulting in a fine loose powder which is directly available from the product collectorMaterial consistencies can range from solutions dispersions to paste and even wet solidsThe key benefits of this technology are efficiency minimal handling and anbspconsistent highnbspproduct quality.
The Nauta mixer is a conical screw mixer specially designed for segregative freeflowing powders and pastesNauta who developed the first conical Nauta mixer in 1939In 1982 Hosokawa Micron acquired the Nautamix companyEver since the original model has been under continuous development and kept being successful.
The versatile Conical Paddle Dryer by Hosokawa Micron offers extremely fast batch drying in a compact design and is available in a range of sizes from 5 to 15000 litresA quicker and less labour intensive freeze drying process with the potential to produce a fine loose powder of even the most sensitive and precious.
This video shows that the Hosokawa Micron Ltd Group is the pioneer of Active freeze drying lyophilizationPeter van de Wel from Hosokawa Micron conducted the presentation at NetherlandsFreeze drying technique is used in industries for decades to preserve biological materials and foodstuffsThe traditional type freeze dryers are labor intensive and slow.
Typical applications of this new technology are to be expected in eThe production of probiotics bacteria as food additives pharmaceuticals and new nano materials.
Until now freeze dryers are all of the tray dryer typeDespite the optimal structure of the individual product particles the product layer on the plates will usually form one piece of hard baked materialOften the product has to be crushed after freeze drying which may lead to damage to the product structureAnother disadvantage could be the relative low heat transfer rate due to the quiescent state of the materialAlso the handling of the product is quite labour intensive because the trays have to be filled and discharged manually.
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